| The CSIR (Council of Scientific and Industrial | | | | Phenfen, but a natural food. During clinical studies, |
| Research) of South Africa patented a native plant, | | | | there were no side effects reported. The fact that |
| growing wild in the Kalahari Desert, as an aid to | | | | Hoodia Gordonii products are classified as a food and |
| weight loss programs. Hoodia Gordonii, as the plant is | | | | not a drug is indicative of the safety of the product. |
| called, suppresses hunger. The San tribe, who live on | | | | Supermarkets are selling it as a food supplement. |
| the fringes of the Kalahari Desert, used it for | | | | Any harmful effect from Hoodia products is caused |
| thousands of years for that purpose. CSIR isolated a | | | | by misuse. People with eating disorders force |
| molecule, named P 57, as the active agent that | | | | themselves to eat because of the hunger. But now |
| created the feeling of fullness. | | | | they can pop a pill and go about without discomfort. |
| P 57 initiates glucose and induces the nerve cells in | | | | That would prove to be very dangerous to their |
| the hypothalamus, the midbrain, to fire signals that | | | | health. Another safety hazard is the adulteration of |
| give a feeling of fullness. P 57 is about 10,000 times | | | | Hoodia. As the plant is in short supply, adulteration by |
| as effective as glucose. CSIR struck an agreement | | | | the suppliers is rampant. Some manufacturers, |
| with the British company Phytopharm to test, | | | | knowing this, attempt to make their product |
| develop and market the product. Phytopharm did the | | | | effective by adding stimulants like ephedrine and |
| only serious clinical study and published its results. In a | | | | caffeine. This may create unspecified side effects. |
| double blind study, P 57 reduced the intake of | | | | The only clinical study done by Phytopharm was not |
| calories by 1,000. | | | | a long-term one, so the long-term side effects are |
| P 57 is not a chemical stimulant like Ephedra or | | | | still an unknown factor. |