How Therapeutic Ultrasounds Became Used to Remove Fat

Since instant fat reduction holds great appeal,Love" a Cologne surgeon called Josef Schrudde
liposuction has become the most common cosmeticdecided to try out the technique again of someones
procedure performed worldwide. According to theankles.
American Society of Plastic Surgeons (ASPS), theThe second attempt was much more successful and
number of liposuction procedures performedthankfully the patient lived to tell the tale. In 1974, an
increased by 386 percent from 1992 to 2000. MoreItalian gynaecologist called Giorgio Fischer further
than 450,000 liposuction pro- cedures weredeveloped the technique with the invention of an
performed in 2005. Interestingly, 21% of theseelectrical, rotating scalpel encapsulated by a cannula
procedures were ultrasound-assisted lipoplasty (UAL).that suctioned out dislodged cells. In 1978 the
The American public spend an estimated $2 billion fortechnique was taken to Paris where it was refined
these operations. The basic technique involvesand popularised by the French plastic surgeon
inserting a narrow tube (cannula) under the skinYves-Gerard Illouz. In 1982, Illouz presented a new
through tiny incisions and manipulating the cannula toform of lipolysis using blunt cannulas and high-vacuum
break up and suction out fat cells. The proceduresuction with reproducible good results and low
injures other local tissue, causing temporary bruising,morbidity and a new age of liposuction arrived. It was
swelling and blood loss. The areas most commonlythe same year that American film actress Princess
treated are the outer thighs and abdomen in womenGrace died on a mountain road in Monaco.
and the flanks or "love handles" in men.During the eighties other cannulae were developed
Liposuction can also remove unwanted fat from hips,by Kesselring and Meyer while the father of aesthetic
buttocks, knees, upper arms, chin, cheeks, neck andmedicine Pierre Fournier developed another technique
other areas. The concept behind liposuction seemsusing a syringe. In this period lipo- suction reached the
almost too good to be true: However, it isn't an easyUnited States but quickly fell out of favour because
fix. The American Society of Plastic Surgeons (ASPS)of increased complications and several deaths. It now
warns that liposuction is a serious surgical procedureappears that many of the deaths related to Plastic
that involves a potentially painful recovery and risksSurgeons com- bining liposuction with abdominoplasty
of rare but serious complications. A decision as to"tummy tucks." In 1985 a Californian Dermatologist,
whether to undergo liposuction, according to theJeffrey Klein, invented and pioneered a new
American Mayo Clinic, should be considered verytumescent method Technique, the safest method
carefully. Nevertheless, liposuction is a popular choice.known. He was helped in this development by a
However, now there may be a new ultrasonicColorado dermatologist, Patrick Lillis. In 1987, an Italian
method of removing fat from the body that involvesPlastic Surgeon from La Sapienza University in Rome
no risk to the patient. This new method calledcalled Professor Nicolo Scuderi introduced the use of
UltraShape ® uses unique G-NIUS(TM) (Guidedultrasound as an emulsifying modality for fat tissue
Non-Invasive Focused Ultrasound Selective)during liposuction and a new age of 'fat busting'
technology to effectively and safely break down fatbegan. This technique was further modified when
cells. The use of external ultrasound means theZocchi introduced titanium ultrasonic probes and
patient does not even have to undergo any invasivemanual remodelling of the treated areas to eliminate
surgical procedure. The UltraShape procedure has thethe fluid from the burst fat cells in 1992. It was the
potential to redefine aesthetic medicine by developingsame year that Democratic Party candidate William J.
a non-invasive means for fat removal.Clinton was swept to power in the US presidential
Therapeutic ultrasound (in contrast to diagnostic andelection and the world witnessed three days of
imaging modalities) has been used as a therapeuticrioting in Los Angeles after four white police officers
tool in medicine for more than fifty years. The firstwere acquitted of criminal charges despite video
ultrasonic machine (lithotripter) used to destroyevidence they had beaten black motorist Rodney
kidney stones was produced by the German AircraftKing.
manufacturer Dornier in Munich in 1980. It was theIn 1998, Californian Plastic Surgeon, Barry Silberg
same year that the former Beatle, John Lennon, waselaborated on the technique using external
shot dead outside his New York apartment. In 1984,ultrasound-assisted liposuction (XUAL). This method
the company introduced the Dornier HM-3 (Humanrequired traditional aspirative liposuction after the
Model-3) and in that same year the FDA approvedapplication of high frequency ultrasonic fields delivered
the use of ESWL (extracorporeal shock wavethrough the skin into a wetted tissue. Silberg felt that
lithotripsy) in the United States for the treatment ofthis method led to less traumatic surgery with
renal calculi. Since that time, the HM-3 or the "Munichsuperior clinical outcome. There is little doubt as an
Stonebuster" as the press preferred to call it hasinvasive modality, like tumescent liposuction, the
treated over five million patients worldwide. By 1985,technique still had many of the drawbacks that
the technique was first applied successfully in aaccompany invasive procedures. Moreover, many
patient with gallbladder stones. It was the same yeardoctors started to voice opinions that the magnitude
that the energetic Dubliner, Bob Geldof, had the ideaof ultrasonic energy used to destroy the fat cells
of organising Live Aid for the starving people ofmay also damage other tissue in contact with the
Africa.cannula. Many felt one of the technical drawbacks of
In the following years, many conditions suitable forthe ultrasonic liposuction technique was that the
the technique of ESWL were investigated. But thecannula had to be inside the body. It was at this
story of using therapeutic ultrasound in medicine didstage a Tel Aviv plastic surgeon called Ami Glicksman
not really start there. In fact it may haveconsidered the possibility of using external ultrasonic
inadvertently started with another aircraftwaves to selectively break down fat cells without
manufacturer because during World War 2, Britishthe patient having to undergo a surgical procedure.
ophthalmic surgeon Harold Ridley, noticed pieces ofIn 2001, while the rest of the world was getting to
Plexiglas from the shattered canopies of Spitfiregrips with the aftermath of an Al Qaeda terrorist
fighter planes did not cause any reaction when theyattack on the World Trade Centre in New York, Dr.
became embedded in pilot's eyes. He used thisGlicksman was in Tel Aviv researching the feasibility
theory to use the material to implant the world's firstof using external ultrasound to break down fat cells
intraocular lens, at St. Thomas Hospital in London onin pigs. His experiments were successful and he noted
Nov. 29, 1949. The next year he encounteredthat fat lysis was selective leaving nearby tissues
widespread criticism from his peers at a conferenceintact. Further macroscopic and microscopic analyses
in the United States who considered the idea ofof overlying skin noted that it also remained
replacing the eye's natural lens with an artificial oneuntouched. The researchers quickly moved from the
too radical and unacceptable for the period.pig models and tried the external ultrasound
Over the next twenty years the idea of lenstransducer to lyse human fat from ex vivo tissue
implants for cataracts slowly became moreharvested from skin fiaps excised in hospital
acceptable. In 1968, American surgeon, Charlesabdominoplasty procedures. These experiments also
Kelman adapted the new technology of ESWL toshowed fat lysis only occurred in a specific region,
remove cataracts. The procedure, later known asleaving skin or fat outside of the focused beam
phacoemulsification, used a tiny probe with a vibratingintact. The temperature on the skin and within the
tip to gently break up the cataract and wash it away.focus was monitored and showed an increase of 1oC
The techniques of phacoemulsification and plastic lensfor an ultrasound treatment of 1-2 seconds. Further
implant technology were combined and the sciencehuman in-vivo trials were commenced in Israel with
of cataract surgery was revolutionised. In 1981, aparticipants being treated with the ultrasonic device
protégé of Ridley called Choyceprior to abdominoplasty in which the treated area
gained the first FDA approval of intraocular lenses. Itwas removed and analysed. The first study of
was the same year that Irish Republican hungertwenty patients commenced in 2002 monitoring the
striker, Bobby Sands died in the Maze prison. Today,safety and effectiveness of the treatment.
after decades of development, modernHistological evaluation of all tissues excised during
phacoemulsification is considered one of the safestsurgery clearly showed that the external ultrasound
surgeries performed with millions of successfultreatment only destroyed adipose cells, leaving blood
procedures completed every year around the world.vessels, connective tissue, nerves, and epidermis
Today the use of therapeutic ultrasound in the formintact.
of extracor-poreal shock wave therapy has found itsIn 2003, a US-organised coalition invaded Iraq with
way into many other facets of medicine with recentthe stated reason that it had not abandoned its
advances in machines designed specifically for use onnuclear and chemical weapons development program
arms and legs to treat the chronic localised pain thataccording to UN resolutions. In that year also, a large
is associated with chronic tendonitis. However, itsmulti-centre clinical trial with the external ultrasound
main use may yet prove to be the most interestingdevice started in five sites in the USA, UK, and
as the "Tel Aviv Fat- buster". In fact the associationJapan, in which 137 patients underwent a single
of ultrasound with the destruction of fat cells startstreatment. The results showed that on average a 2
many years before. It may have started as far backcm reduction in circumference was observed
as 1921, when a French surgeon called Dujarrier,post-treatment. This approximates to about 0.5 litres
decided to practice the new art of liposuction in anand the rest may be removed with a further
attempt to create a better shape on a youngprocedure performed one month later. The device
ballerina's knees. Unfortunately his patient developedhas now obtained CE approval in Europe and more
gangrene and required an amputation. It was thethan 500 individuals have been commercially treated
same year that the new Irish Free State waswith the device in the Ireland, UK, Spain and
established. After this initial fiasco, things remainedScandinavia, demonstrating the safety and
quiet for many years, through the advent ofeffectiveness of the treatment. FDA trials are
antibiotics, the Second World War and while thepresently underway with all expectations that they
Beatles were racing up the charts with "Can't Buy Mewill shortly approve the procedure.